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Hiroshi Higuchi

Managing Partner

Patent Attorney
Qualified as a Litigating Patent Attorney (“Huki-Benrishi”)
U. S. Patent Agent (Limited Recognition, 2008)

Hiroshi Higuchi is the managing partner of Allegro IP Law Firm. With more than 18 years of experience in the field of intellectual property law, Hiroshi handles patent matters in Japan for the most advanced companies and universities across the world. Before founding Allegro IP, Hiroshi was an attorney with Yanagida & Associates and served as the leader of the foreign clients team. Prior to joining the Yanagida firm, he was an in-house attorney with a Fortune Global 500 company and a US Patent Agent with a large boutique IP firm in DC area. He is qualified as a litigating attorney and received a bachelor’s degree from the University of Tokyo.

Practice Area

Chemistry / Biotechnology / Life Sciences / Medical Devices / Trademarks


Yanagida & Associates
Sughrue Mion PLLC (trainee)
Bridgestone Corporation (IP Department / IP Administration and License Unit)


The University of Tokyo (B. S., Agricultural and Life Sciences, Aquatic Animal Physiology)

樋口 洋

弁理士 特定侵害訴訟代理業務付記

Sughrue Mion PLLC


Speaker | New ruling on protection of extended pharmaceutical patent rights in Japan| AIPLA Mid-Winter Institute IP Practice in Japan Committee Pre-meeting: January 2019
Protection of adidas Three-Stripes trademark protection in Japan – INTA in San Francisco: May 2011
Speaker | CAFC – Cordis Corp. v. Boston Scientific Corp. (Written Description)| JPAA International Activities Center: April 2011
Speaker | IP High Court – Yokohama Rubber v. Yonex (Doctrine of Equivalents)| AIPLA Annual Meeting IP Practice in Japan Committee Pre-meeting: October 2009

JPAA (Japan Patent Attorneys Association)
– International Activities Center, JP Division | AIPLA PG | IPO PG, 2018-2019
– International Activities Center, EP Division, 2012
– International Activities Center, US Division, 2011
FICPI (International Federation Intellectual Property Attorneys)
INTA (International Trademark Association)
APAA (Asian Patent Attorneys Association)

Kaori Kohno


Patent Attorney
Radiation Protection Supervisor

Kaori Kohno brings an extensive technical background to her intellectual property law practice, focusing primarily on pharmaceuticals, biotechnology, and chemistry matters. She counsels clients on complex patent procurement matters. She has over 20 years of experience as a prosecutor before the Japan Patent Office. In addition to her prosecution experience, Kaori has developed vast experience in complex proceedings, such as appeals and oppositions. Before joining Allegro IP, she was an attorney with Yanagida & Associates. Prior to entering law practice, she served as a Pharmacist and a Radiation Protection Supervisor. She received a master’s degree from Kyoto University.

Practice Area

Pharmaceutical / Biotechnology / Chemistry


Yanagida & Associates
Food Products Company (R&D Medical Products)
Ehime University (Department of Radiology)


Kyoto University (B. S., Pharmaceutical Sciences)
Kyoto University (M. S., Pharmaceutical Sciences)

河野 香




Tsuyoshi Sakuma

Senior Counsel

Patent Attorney
Qualified as a Litigating Patent Attorney (“Huki-Benrishi”)

Tsuyoshi Sakuma is one of Japanese leading intellectual property experts. He has over 30 years of experience in handling patent matters in a wide variety of technologies including the electrical, mechanical, and software arts. He is also an expert in the fields of copyright, design and trademark matters. Tsuyoshi guides clients through complex procurement and litigation matters. Prior to entering legal practice, he was an engineer at the R&D division with a Fortune Global 500 company. He received a bachelor’s degree from Hiroshima University.

Practice Area

Mechanical Engineering / Physics / Trademarks / Designs


Yanagida & Associates (Vice President)
Domestic IP Law Firm
Hitachi Chemical Co., Ltd. (R&D)


Hiroshima University (B. S., Mechanical Engineering)

佐久間 剛

弁理士 特定侵害訴訟代理業務付記



Takahisa Murata, DVM, Ph.D.

Technical Advisor

Associate Professor in Graduate School of Agriculture and Life Science, the University of Tokyo

Dr. Murata’s Laboratory

Practice Area

Pharmaceutical / Biotechnology / Animal Medicine / Vaccine / Immunity


Assistant Professor, Department of Veterinary Pharmacology, the University of Tokyo
Researcher, Yale University School of Medicine


The University of Tokyo (M. S., Veterinary Medicine)
The University of Tokyo (Ph.D., Veterinary Medicine)

村田 幸久

東京大学大学院 農学生命科学研究科放射線動物科学研究室 准教授

日本学術振興会 特別研究員米国Yale大学医学部 研究員
東京大学大学院 農学生命科学研究科 助教


Mast cell-derived PGD2 attenuates anaphylactic reactions in mice. Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, *Murata T.J Allergy Clinical Immunology.2017, in press.
PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi B, Iwakura Y, Urade Y, *Murata T. Nature Communications. 6:7514 2015.
Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, *Murata T. Mast Cell-Derived Prostaglandin D2 Inhibits Colitis and Colitis-Associated Colon Cancer in Mice. Cancer Res. 74(11):3011-9. 2014.
*Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H. Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. Proc Natl Acad Sci U S A. 26;110(13):5205-10.2013.
eNOS derived nitric oxide regulates endothelial barrier function via VE cadherin and Rho GTPases. DiLorenzo A, Lin M, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang P, *Sessa WC. Journal of Cell Science. 126(Pt 24):5541-52. 2013.
*Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H. Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. Proc Natl Acad Sci U S A 108(49):19802-7. 2011.

SHIMADZU Global Innovation Summit Award, A Novel Biomarker of Food Allergy, 2017
The Japanese Vascular Biology and Medicine Organization, Young Investigator Highest Award, Development of a vascularization promoting agent, 2016
Japanese Cancer Association, Incentive Award, Discovery of a molecule inhibiting the development and progression of cancer and therapeutic application thereof, 2016
The Japanese Vascular Biology and Medicine Organization, Young Investigator Award, Mast cell-derived PGD2 inhibits neoangiogenesis in lung carcinoma, 2011